Validation Record
CLL / MCL / WM · Report ID: BENCH::BTK::creaim-btk-sealed-holdout-v1::1.0::Engine 25 v1.9 · Engine Engine 25 v1.9
BENCHMARKEDProvenance
Run-Level Pipeline Evidence
Persisted-record presence only. RECORDED/COMPLETE does not mean independent scientific validation.
1 · Molecule / Target Identity
RECORDEDTarget: BTK
Anchor: creaim-btk-sealed-holdout-v1
2 · Scientific Evidence
RECORDEDCoverage: Benchmark Dataset
Anchor: NOT RECORDED
3 · Runtime Computing
COMPLETE14940 persisted runtime states
Anchor: BENCH::BTK::creaim-btk-sealed-holdout-v1::1.0::Engine 25 v1.9
4 · Decision
RECORDEDDecision: PASS
Anchor: BENCH::BTK::creaim-btk-sealed-holdout-v1::1.0::Engine 25 v1.9
5 · Decision Freeze
NOT_RECORDEDFreeze hash not recorded
Anchor: NOT RECORDED
6 · Biological Cross-Validation
NOT_RECORDEDIndependent cross-validation not recorded
Anchor: NOT RECORDED
7 · Blind / Live Validation
NOT_RECORDEDFrozen GroundTruth linkage not recorded
Anchor: NOT RECORDED
8 · Validation Maturity
RECORDEDCurrent registry status: BENCHMARKED
Anchor: BENCH::BTK::creaim-btk-sealed-holdout-v1::1.0::Engine 25 v1.9
Runtime Result
Internal Retrospective Benchmark Metrics — persisted frozen labels
Tested Compounds
15
Known Actives
5
Active Retention
80.0%
Precision
100.0%
Recall
80.0%
False Negative Rate
20.0%
Candidate Reduction
N/A
Enrichment Factor
N/A
These values are read from the run's frozen benchmark labels. They are not independent external validation, wet-lab confirmation, or overall predictive accuracy.
Separately Attached GroundTruth Records (0)
No separate GroundTruth entity records are attached. The metrics above use frozen benchmark labels persisted on this run.
Cross-Database External Evidence
Stage 7 · Read-only · v1.11Cross-DB SUPPORT ≠ VERIFIED · WormBase ≠ Wet-Lab · Real Evidence ≠ AUTHORITATIVE
Sources
0/5
Total Evidence
0
Matched
0
Conflict/Unresolved
0
Missing
0
VERIFIED / AUTHORITATIVE status is NOT derived from source presence. No score computed. No report recompute. Engine 25 / Stage 6 / Decision v1 unchanged.
Biological Cross-Validation
Stage 7 · Read-only · v1.11Cross-DB SUPPORT ≠ VERIFIED · WormBase ≠ Wet-Lab · Network proximity ≠ efficacy · Real Evidence ≠ AUTHORITATIVE
Source Coverage
0/7
Conflicts
0
Missing Axes
7
Provenance Complete
NO
Live Validation · Maturity · Authority
API / database SUPPORT only · VERIFIED / AUTHORITATIVE / Wet-Lab CONFIRMED require independent reviewer (C10) + qualifying wet-lab trace (C12).
canonical projection · read-only · no recompute · no new score
PREDICTION FIRST → NEW EVIDENCE LATER → COMPARE · read-only · Selection v1 immutable