C
CREAIM PHARMA
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Validation Record

EGFR

EGFR / ALK / KRAS inhibitor benchmark · Report ID: BENCH::EGFR::creaim-kinase-public-v1::1.0::Engine 25 v1.8 · Engine Engine 25 v1.8

BENCHMARKED

Provenance

Source
PUBLIC_BENCHMARK
Dataset ID
N/A
Dataset Version
N/A
Runtime ID
BENCH::EGFR::creaim-kinase-public-v1::1.0::Engine 25 v1.8
Report ID
BENCH::EGFR::creaim-kinase-public-v1::1.0::Engine 25 v1.8
Engine Version
Engine 25 v1.8
Rule Version
NOT RECORDED
Evidence Anchor
NOT RECORDED
Result Hash
NOT RECORDED
Decision Hash
NOT RECORDED
GroundTruth Set / Version
NOT LINKED / N/A
GroundTruth Hash
NOT RECORDED
Frozen / Unblinded
NOT RECORDED / NOT RECORDED
Execution Date
8/3/2026, 12:20:01 AM

Run-Level Pipeline Evidence

Persisted-record presence only. RECORDED/COMPLETE does not mean independent scientific validation.

1 · Molecule / Target Identity

RECORDED

Target: EGFR

Anchor: creaim-kinase-public-v1

2 · Scientific Evidence

RECORDED

Coverage: Benchmark Dataset

Anchor: NOT RECORDED

3 · Runtime Computing

COMPLETE

20916 persisted runtime states

Anchor: BENCH::EGFR::creaim-kinase-public-v1::1.0::Engine 25 v1.8

4 · Decision

RECORDED

Decision: PARTIAL

Anchor: BENCH::EGFR::creaim-kinase-public-v1::1.0::Engine 25 v1.8

5 · Decision Freeze

NOT_RECORDED

Freeze hash not recorded

Anchor: NOT RECORDED

6 · Biological Cross-Validation

NOT_RECORDED

Independent cross-validation not recorded

Anchor: NOT RECORDED

7 · Blind / Live Validation

NOT_RECORDED

Frozen GroundTruth linkage not recorded

Anchor: NOT RECORDED

8 · Validation Maturity

RECORDED

Current registry status: BENCHMARKED

Anchor: BENCH::EGFR::creaim-kinase-public-v1::1.0::Engine 25 v1.8

Runtime Result

Evaluated Candidates
21
Eligible / Ineligible
21 / 0
Lead / Backup
Gefitinib / Erlotinib
Runtime States (PASS/HOLD/KILL)
13752/7164/0
Evidence Coverage
Benchmark Dataset
FTO Risk
Primary Decision Driver
Benchmark Comparison
Final Decision
PARTIAL
Next Action
Investigate missed actives

Internal Retrospective Benchmark Metrics — persisted frozen labels

Tested Compounds

21

Known Actives

11

Active Retention

100.0%

Precision

52.4%

Recall

100.0%

False Negative Rate

0.0%

Candidate Reduction

N/A

Enrichment Factor

N/A

These values are read from the run's frozen benchmark labels. They are not independent external validation, wet-lab confirmation, or overall predictive accuracy.

Separately Attached GroundTruth Records (0)

No separate GroundTruth entity records are attached. The metrics above use frozen benchmark labels persisted on this run.

Cross-Database External Evidence

Stage 7 · Read-only · v1.11

Cross-DB SUPPORT ≠ VERIFIED · WormBase ≠ Wet-Lab · Real Evidence ≠ AUTHORITATIVE

Sources

0/5

Total Evidence

0

Matched

0

Conflict/Unresolved

0

Missing

0

SOURCEOpen TargetsOPEN_TARGETS_ANNOTATION
0 records
No evidence records from this source.
SOURCEReactomeREACTOME_PATHWAY
0 records
No evidence records from this source.
No WormBase evidence records.
SOURCEC. elegans ExperimentC_ELEGANS_EXPERIMENT
0 records
No evidence records from this source.
SOURCEDepMapDEPMAP_ONCOLOGY
0 records
NOT_AVAILABLE — bulk dataset + license not secured. No rows persist.

VERIFIED / AUTHORITATIVE status is NOT derived from source presence. No score computed. No report recompute. Engine 25 / Stage 6 / Decision v1 unchanged.

Biological Cross-Validation

Stage 7 · Read-only · v1.11

Cross-DB SUPPORT ≠ VERIFIED · WormBase ≠ Wet-Lab · Network proximity ≠ efficacy · Real Evidence ≠ AUTHORITATIVE

Open Targets
NOT_AVAILABLE
Reactome
NOT_AVAILABLE
WormBase
NOT_AVAILABLE
C. elegans
NOT_AVAILABLE
GTEx
NOT_AVAILABLE
ClinVar
NOT_AVAILABLE
STRING
NOT_AVAILABLE

Source Coverage

0/7

Conflicts

0

Missing Axes

7

Provenance Complete

NO

Live Validation · Maturity · Authority

Live Validation (Stage 7)
COMPARISON ONLY
Validation Maturity
BENCHMARKED
VERIFIED
NO
AUTHORITATIVE
NO
Wet-Lab Status
SEPARATELY DISPLAYED

API / database SUPPORT only · VERIFIED / AUTHORITATIVE / Wet-Lab CONFIRMED require independent reviewer (C10) + qualifying wet-lab trace (C12).

Stage 5 · ValidationRunDetail

Scientific Candidate Selection

canonical projection · read-only · no recompute · no new score

No canonical Scientific Candidate Selection object is available.
SCIENTIFIC_SELECTION=NOT_AVAILABLE
Stage 5 · ValidationRunDetail

Prospective Validation Result

PREDICTION FIRST → NEW EVIDENCE LATER → COMPARE · read-only · Selection v1 immutable

No canonical Selection object — Prospective Validation cannot be projected.
PROSPECTIVE_VALIDATION=NOT_YET_AVAILABLE
Created: 8/3/2026, 12:20:01 AM · Last Updated: 8/3/2026, 12:20:02 AM